Klaus F Rabe Selected Research

itepekimab

11/2021	Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial.
10/2021	Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma.

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Klaus F Rabe Research Topics

Disease

92	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 02/2002
58	Asthma (Bronchial Asthma) 01/2022 - 02/2002
30	Inflammation (Inflammations) 01/2022 - 02/2002
12	Lung Diseases (Lung Disease) 11/2021 - 01/2002
12	Chronic Bronchitis 11/2018 - 10/2010
9	Neoplasms (Cancer) 03/2022 - 08/2005
8	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2022 - 12/2003
7	Infections 01/2021 - 11/2003
6	Lung Neoplasms (Lung Cancer) 03/2022 - 11/2005
6	COVID-19 02/2022 - 01/2020
6	Eosinophilia 01/2018 - 04/2002
5	Fibrosis (Cirrhosis) 12/2021 - 10/2010
5	Dyspnea (Shortness of Breath) 08/2021 - 10/2009
5	Pneumonia (Pneumonitis) 01/2020 - 10/2010
4	Obesity 01/2022 - 11/2014
3	Respiratory Tract Diseases (Respiratory Tract Disease) 09/2022 - 04/2013
3	Cystic Fibrosis (Mucoviscidosis) 12/2021 - 01/2002
3	Nasopharyngitis 11/2021 - 10/2018
3	Disease Progression 01/2021 - 09/2010
3	Nausea 01/2021 - 10/2004
3	Airway Obstruction (Choking) 01/2020 - 11/2003
3	Hypersensitivity (Allergy) 01/2020 - 10/2004
3	Cough 11/2018 - 12/2005
3	Emphysema 11/2017 - 10/2012
3	Lymphatic Metastasis 09/2011 - 12/2003
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 01/2020
2	Headache (Headaches) 11/2021 - 08/2009
2	Respiratory Tract Infections (Respiratory Tract Infection) 11/2021 - 10/2018
2	Obstructive Lung Diseases (Obstructive Lung Disease) 01/2021 - 01/2017
2	Idiopathic Pulmonary Fibrosis 01/2021 - 01/2002
2	Atopic Dermatitis (Atopic Eczema) 01/2020 - 05/2018
2	Rhinosinusitis 01/2020 - 01/2020
2	Adenocarcinoma 11/2019 - 11/2017
2	Bronchiectasis 01/2019 - 01/2019
2	Respiratory Hypersensitivity 01/2019 - 05/2008
2	Heart Failure 05/2017 - 09/2016
2	Necrosis 09/2016 - 12/2007
2	Fatigue 01/2016 - 01/2016

Drug/Important Bio-Agent (IBA)

33	Adrenal Cortex Hormones (Corticosteroids)IBA 02/2022 - 01/2003
20	Bronchodilator Agents (Bronchodilators)IBA 05/2020 - 01/2003
19	Biomarkers (Surrogate Marker)IBA 03/2022 - 10/2007
19	RoflumilastIBA 11/2018 - 08/2005
16	Formoterol Fumarate (Oxis)FDA Link 01/2022 - 12/2005
12	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 01/2018 - 02/2002
11	Glycopyrrolate (Glycopyrronium Bromide)FDA LinkGeneric 01/2022 - 01/2017
11	Tiotropium Bromide (Spiriva)FDA Link 01/2021 - 08/2008
11	GoldIBA 01/2021 - 09/2006
10	Budesonide (Pulmicort)FDA LinkGeneric 01/2022 - 02/2006
10	SteroidsIBA 01/2022 - 05/2002
9	Pharmaceutical PreparationsIBA 02/2022 - 03/2011
9	GlucocorticoidsIBA 10/2021 - 10/2012
8	dupilumabIBA 01/2022 - 01/2018
8	Monoclonal AntibodiesIBA 11/2021 - 04/2009
7	budesonide-glycopyrrolate-formoterol fumarate drug combinationIBA 08/2021 - 10/2018
7	Muscarinic AntagonistsIBA 01/2020 - 01/2012
7	Anti-Bacterial Agents (Antibiotics)IBA 01/2019 - 09/2011
6	Biological ProductsIBA 01/2021 - 01/2016
6	SuspensionsIBA 01/2020 - 02/2017
6	Phosphodiesterase 4 InhibitorsIBA 01/2014 - 12/2007
6	Salmeterol Xinafoate (Serevent)FDA Link 01/2014 - 08/2008
5	C-Reactive ProteinIBA 01/2022 - 01/2006
5	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2021 - 04/2002
4	CollagenIBA 12/2021 - 12/2012
4	Interleukin-13IBA 01/2021 - 05/2018
4	CytokinesIBA 01/2021 - 10/2004
4	Cholinergic Antagonists (Anticholinergics)IBA 01/2012 - 01/2010
4	Interleukin-8 (Interleukin 8)IBA 12/2007 - 11/2003
3	SmokeIBA 09/2022 - 11/2005
3	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2008
3	Interleukin-4 (Interleukin 4)IBA 10/2021 - 01/2020
3	Volatile Organic CompoundsIBA 01/2021 - 10/2007
3	Albuterol (Salbutamol)FDA LinkGeneric 01/2019 - 01/2008
3	EnzymesIBA 01/2016 - 05/2011
3	AllergensIBA 04/2005 - 08/2002
2	Cholecalciferol (Vitamin D3)FDA Link 02/2022 - 01/2015
2	Interleukin-33IBA 11/2021 - 10/2021
2	itepekimabIBA 11/2021 - 10/2021
2	Immunoglobulin E (IgE)IBA 10/2021 - 01/2021
2	Interleukin-5 (Interleukin 5)IBA 10/2021 - 01/2021
2	DNA (Deoxyribonucleic Acid)IBA 06/2021 - 10/2015
2	pirfenidoneIBA 01/2021 - 01/2019
2	tiotropium-olodaterolIBA 01/2021 - 01/2018
2	InterleukinsIBA 01/2021 - 05/2018
2	RNA (Ribonucleic Acid)IBA 01/2021 - 11/2019
2	2- n- butyl- 3- (dimethylamino)- 5,6- methylenedioxyindeneIBA 05/2020 - 01/2019
2	Troponin IIBA 01/2020 - 09/2016
2	Transforming Growth Factor beta (TGF-beta)IBA 01/2019 - 10/2004
2	NitrogenIBA 01/2019 - 01/2015
2	Methacholine Chloride (Methacholine)FDA Link 01/2019 - 07/2007
2	prednylidene (Pred)IBA 05/2017 - 02/2015
2	Oxygen (Dioxygen)IBA 01/2016 - 01/2006
2	Antimicrobial PeptidesIBA 01/2015 - 05/2011

Therapy/Procedure

54	Therapeutics 03/2022 - 08/2002
10	Metered Dose Inhalers (Metered Dose Inhaler) 01/2021 - 01/2017
4	Nebulizers and Vaporizers (Inhaler) 01/2021 - 02/2006
4	Thoracotomy 12/2017 - 08/2005
2	Subcutaneous Injections 11/2021 - 04/2009
2	Biological Therapy 10/2020 - 05/2018
2	Respiratory Therapy (Therapy, Respiratory) 01/2016 - 01/2013
2	Pneumonectomy (Lung Volume Reduction) 01/2016 - 06/2005